MyBioSource.com's Anti-IL18 Antibody is a Polyclonal antibody. This antibody has been shown to work in applications such as: Western Blot. The Anti-IL18 Antibody was generated using IL-18, IL18, and Interleukin 18 as the antigen and it reacts with Mouse.
Description
Description: Rabbit IgG polyclonal antibody for Interleukin-18(IL18) detection. Tested with WB in Mouse.
Background: Interleukin-18, also known as IL18, is a protein which in humans is encoded by the IL18 gene. IL-18 is a cytokine produced by macrophages and other cells that belongs to the IL-1 superfamily. It is mapped to 11q22.2-q22.3. IL-18 works by binding to the interleukin-18 receptor, and together with IL-12, it induces cell-mediated immunity following infection with microbial products like lipopolysaccharide (LPS). After stimulation with IL-18, natural killer (NK) cells and certain T cells release another important cytokine called interferon-gamma (IFN-gamma) or type II interferon that plays an important role in activating the macrophages or other cells. The combination of this cytokine and IL12 has been shown to inhibit IL4 dependent IgE and IgG1 production, and enhance IgG2a production in B cells